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Wei-Chieh Cheng Selected Research

Fabry Disease (Fabry's Disease)

1/2018Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell lines.
1/2017Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries to discover a pharmacological chaperone for treatment of Fabry disease.
11/2016Bioevaluation of sixteen ADMDP stereoisomers toward alpha-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency.

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Wei-Chieh Cheng Research Topics

Disease

3Infections
01/2021 - 04/2012
3Fabry Disease (Fabry's Disease)
01/2018 - 11/2016
3Gaucher Disease (Gaucher's Disease)
09/2013 - 11/2002
1Hepatocellular Carcinoma (Hepatoma)
06/2022
1COVID-19
01/2021
1Bacterial Infections (Bacterial Infection)
04/2012
1Human Influenza (Influenza)
11/2010
1Osteoarthritis
01/2006
1Anemia
11/2002

Drug/Important Bio-Agent (IBA)

2EnzymesIBA
01/2018 - 11/2002
2Glucosylceramidase (Glucocerebrosidase)IBA
09/2013 - 11/2005
1Polysaccharides (Glycans)IBA
06/2022
1Plant ExtractsIBA
01/2021
1Pharmaceutical PreparationsIBA
01/2021
1pyrrolidineIBA
01/2017
1alpha-Galactosidase (Beano)IBA
11/2016
1moenomycinIBA
07/2015
1Anti-Bacterial Agents (Antibiotics)IBA
04/2012
1Peptidyl Transferases (Peptidyltransferase)IBA
04/2012
1VaccinesIBA
04/2012
1Proteins (Proteins, Gene)FDA Link
11/2010
1NucleoproteinsIBA
11/2010
1RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA
11/2010
1N-acetyltalosaminuronic acid (NAT)IBA
11/2010
1Glycoside Hydrolases (Endoglycosidases)IBA
01/2006
1Antiviral Agents (Antivirals)IBA
01/2006
1beta-N-AcetylhexosaminidasesIBA
01/2006
1Glycoproteins (Glycoprotein)IBA
01/2006
1alpha-Glucosidases (Acid Maltase)IBA
01/2006
1Glucosylceramides (Glucocerebrosides)IBA
11/2002
1beta-GlucosidaseIBA
11/2002
1N-nonyl-1-deoxynojirimycinIBA
11/2002

Therapy/Procedure

2Enzyme Replacement Therapy
11/2016 - 11/2002
1Therapeutics
01/2006